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A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis

Edited by Franz Joel Leong, Veronique Dartois, Thomas Dick

CRC Press – 2010 – 236 pages

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  • Add to CartPaperback: $129.95
    978-1-43-983527-2
    September 17th 2010

Description

An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, students, scientists, and doctors working, learning, and teaching in the field of TB. It contains 100 color photographs and illustrations that bring clarity to the information presented.

The atlas takes the unusual approach of covering multiple species histopathology, arguably the first and quite possibly the only resource to do so. It provides a simple, annotated, and visual presentation of the comparative histopathology of TB in human and animal models. The editors have compiled information that helps TB scientists to distinguish between the features of all major animal models available and to use them with their strengths and limitations in mind. The book provides guidance for selecting the best animal model(s) to answer specific questions and to test the efficacy of drug candidates.

Reviews

"This book is an excellent introduction to pulmonary tuberculosis and the physiologic, pathologic, and political hurdles as to why it has been such a difficult disease to contend with. The authors explain the intricacies of the tuberculin bacterium, the host defenses, and the theories behind current treatment modalities.

The atlas is designed as a concise resource for researchers working in the field and the laboratory to evaluate the pulmonary pathologic response to the Mycobacterium organism and design more successful treatment and disease eradication for human and animal species. The multitude of photomicrographs and gross pathology photographs are of excellent quality and well-labeled. The text is well written, organized in an easy to read format, and well-referenced for further research."

—Sandra L. Jex, DVM, in alnmag.com

Contents

Drug Discovery for Neglected Diseases of the Developing World, P. Herrling

Background

The Drug Discovery Process

Therapeutic Tools

Drug Discovery Phases

Phase I–Phase IIa

Phase IIb–Phase III

References

Tuberculosis Biology and Drug Discovery, T. Dick

Disease Manifestations and Treatment

A Largely Unment Medical Need

The Challenge of TB Drug Discovery

An At las for TB Drug Discovery

References

Immunopathology of Tuberculosis Disease across Species, V. Dartois

Overview of Species Specific Characteristics

A Macroscopic View of TB-Infected Lungs across Species

Summary and Lessons Learned

References

Anatomy and Histology of the Human Lung, F.J.W.-M. Leong and A. S.-Y. Leong

Gross Structure

Microscopic Structure

References

Pathology of Tuberculosis in the Human Lung, F.J.W.-M. Leong, S. Eum, L.E. Via, and C.E. Barry, 3rd

Introduction

Features

Variations

References

Pulmonary Tuberculosis in Monkeys, J.L. Flynn and E. Klein

Introduction

Inoculum and Route of Infection

Features

Variations

Strengths of This Animal Model

Shortcomings

References

Pulmonary Tuberculosis in the Rabbit, G. Kaplan and L. Tsenova

Introduction

Inoculum and Route of Inoculation

Features

Strengths of This Animal Model

Shortcomings

References

Pulmonary Tuberculosis in the Guinea Pig, R.J. Basaraba and I.M. Orme

Introduction

Inoculum and Route of Inoculation

Features

Strengths of This Animal Model

Shortcomings

References

Pulmonary Tuberculosis in the Rat, A. Singhal, E.M. Aliouat, C. Creusy, G. Kaplan, and P. Bifani

Introduction

Inoculum and Route of Inoculation

Features

Variations

Strengths of This Animal Model

Shortcomings

References

Pulmonary Tuberculosis in the Mouse, S. Bharath and V. Balasubramanian

Introduction

Inoculum and Route of Inoculation

Features

Variations

Strengths of This Animal Model

Shortcoming

References

Glossary

Index

Name: A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis (Paperback)CRC Press 
Description: Edited by Franz Joel Leong, Veronique Dartois, Thomas Dick. An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of...
Categories: Microbiology, Pulmonary Medicine, Laboratory Animal Science