Genome Duplication

Description

This comprehensive and readable overview provides an excellent starting point for undergraduate and graduate students.

Using model organisms from the three domains of life (Bacteria, Archaea, and Eukarya), Genome Duplication describes the principal molecular mechanisms of DNA replication and shows how the process is linked to cell division. This approach allows the authors to shed insight into how genome duplication has evolved, and how its regulation is relevant to the understanding and treatment of human disease, especially cancer.

Contents

1. Genomes 2. Three Domains of Life 3. Replication Forks 4. Replication Proteins: leading-strand synthesis 5. Replication Proteins: lagging-strand synthesis 6. Termination 7. Chromatin Assembly, Cohesion, and Modification 8. Replicons 9. Replication Origins 10. Origin Paradigms 11. Initiation 12. Cell Cycles 13. Checkpoints 14. Human Disease 15. Evolution of Cellular Replication Machines

Related Subjects

1. Molecular Biology
2. Cell Biology
3. Genetics